Perinatal Gene Transfer to the Liver
نویسندگان
چکیده
منابع مشابه
Perinatal Gene Transfer to the Liver
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within the first weeks or months of life is inevitable. Some diseases can be managed using conventional medicines whereas others are, as yet, untreata...
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2. Bismuth H, Chiche L, Adam R, Castaing G. Liver resection versus transvant issue. First-generation recombinant adenoviruses have plantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg associated toxicity, particularly immunogenicity resulting in 1993;218:145-151. inflammation of transduced tissues in vivo. Recent improve3. Iwatsuki S, Starzl T, Sheahan D, Yokoyama I, Demetris...
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Background. Adenoviral gene therapy in liver transplantation has many potential applications, but current vector delivery methods to grafts lack efficiency and require high titers. In this study, we attempted to improve gene delivery efficacy using three different delivery methods to liver grafts with adenoviral vector encoding the LacZ marker gene (AdLacZ). Methods. AdLacZ was delivered to col...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2011
ISSN: 1381-6128
DOI: 10.2174/138161211797247541